Female patients with Takotsubo cardiomyopathy had a significantly higher risk of 30-day all-cause mortality (95% CI: -0.067 to 0.712, p=0.0021) and greater need for mechanical ventilation than males.
Observational (n=120)
Does female gender affect clinical outcomes in patients with Takotsubo cardiomyopathy?
In a retrospective cohort of Takotsubo cardiomyopathy, females had a higher risk of 30-day all-cause mortality and need for mechanical ventilation compared to males, though limited by the small number of male patients.
p-value: p=0.0021
Abstract Background We aim to investigate the association between Takotsubo cardiomyopathy (TCM) and study the gender differences in clinical outcomes. Methods We reviewed 120 cases of Takotsubo syndrome in patients admitted between 2017 and 2022. Demographic data, comorbidities, and hospitalization-related objective parameters were collected through a retrospective chart review. Our primary focus was to examine gender differences in clinical characteristics and outcomes. The clinical outcomes of interest included cardiogenic shock, defined as an LVOT VTI of less than 15 cm or the requirement for two or more vasopressor infusions, as well as the need for invasive mechanical ventilation, length of hospitalization, and all-cause mortality at 30 days. Results A total of 120 patients with Takotsubo cardiomyopathy (TCM) were included in the study, of whom 112 (93%) were female. Among these, 9 patients (7.5%) developed TCM in the setting of septic shock, with diabetes being the most common risk factor in this subgroup, affecting 66% of patients. Demographic summary and clinical characteristics are summarized in Table 1. All-cause mortality was significantly higher among females (95% CI: -0.067 to 0.712, p = 0.0021). The need for mechanical ventilation was also greater in females (95% CI: 0.064 to 0.76, p = 0.015). However, there was no significant difference between groups in the incidence of cardiogenic shock (95% CI: 0.11 to 0.76, p = 0.15). Clinical outcomes are summarized in Table 2. Discussion Takotsubo cardiomyopathy (TCM) was more prevalent among females, with a quarter of cases occurring in critically ill patients in the ICU. This underscores the importance of critical care echocardiography in elucidating the underlying pathophysiology and guiding resuscitation efforts. Females had a higher risk of all-cause mortality and a greater need for mechanical ventilation; however, our findings may be limited by statistical power. We emphasize the need for larger prospective studies to better delineate gender differences in the clinical outcomes of Takotsubo cardiomyopathy. This abstract is funded by: NA
Sedhai et al. (Fri,) conducted a observational in Takotsubo cardiomyopathy (n=120). Female gender vs. Male gender was evaluated on All-cause mortality at 30 days (95% CI -0.067 to 0.712, p=0.0021). Female patients with Takotsubo cardiomyopathy had a significantly higher risk of 30-day all-cause mortality (95% CI: -0.067 to 0.712, p=0.0021) and greater need for mechanical ventilation than males.