The novel PR-HRQOL questionnaire demonstrated moderate and statistically significant correlations with 6MWD, mMRC, CAT, and CRQ total scores (p ≤ 0.01), supporting its construct validity in COPD.
Observational (n=49)
Yes
Does a novel PR-focused HRQOL questionnaire (PR-HRQOL) demonstrate construct validity compared to existing COPD severity measures in patients undergoing pulmonary rehabilitation?
A novel COPD-specific patient-reported outcome measure for pulmonary rehabilitation demonstrates preliminary construct validity by correlating with established functional and quality-of-life measures.
p-value: p=≤0.01
Abstract Introduction Pulmonary rehabilitation (PR) is an important treatment for patients with chronic obstructive pulmonary disease (COPD). However, no specific, patient-reported outcome measures assessing health-related quality of life (HRQOL) are available for those undergoing PR. Existing measures, such as the COPD Assessment Test (CAT) and Chronic Respiratory Questionnaire (CRQ) may not fully capture all key determinants of HRQOL in these individuals. Accordingly, we created and are conducting preliminary validity testing of a novel PR-focused HRQOL questionnaire (PR-HRQOL) for COPD patients undergoing PR. Methods A Delphi consensus panel of patients who completed PR and experienced clinicians completed direct patient-clinician interviews and surveys to identify relevant items for a PR-HRQOL questionnaire. After several iterations, a final instrument consisting of 28 items across 7 domains was created. It includes the following domains: Activity, Social, Psych, Self-Care, Fatigue, Dyspnea, and Sleep. Each item is rated 1-to-5, with lower scores indicating better HRQOL. Total and domain scores are reported as averages ranging from 1-to-5. PR-HRQOL construct validity is being tested in a prospective study by comparing its total and individual domain scores with the following COPD severity measures: FEV1; 6-Minute Walk Distance (6MWD); modified Medical Research Council (mMRC) dyspnea rating; CAT; and CRQ. Spearman correlations between PR-HRQOL and these measures are reported. De-identified data from the four participating Connecticut PR Consortium sites were analyzed centrally by the coordinating site. Results To date, data from 49 participants have been collected, with an enrollment target of 100. The mean (SD) age was 73 (8) years; 59% (29/49) were female; FEV1 was 60% (23%) of predicted; and the PR-HRQOL total score was 2.48 (0.77). Correlation coefficients between total and individual PR-HRQOL domain scores and the comparators are in the Table. No correlations were noted with FEV1 (p ≥ 0.25). However, moderate and statistically significant correlations were observed between the PR-HRQOL total score and 6MWD, mMRC, CAT, and CRQ total scores (p ≤ 0.01). In general, similar correlations were seen between PR-HRQOL domain scores and the comparators. Conclusions This preliminary analysis supports the construct validity of our novel PR-HRQOL questionnaire in that this single questionnaire detects impaired functional exercise capacity, dyspnea burden, and accepted measures of impaired HRQOL. Ongoing testing will evaluate other psychometric properties, including internal consistency, reliability, dimensionality, and responsiveness to PR. Our goal is to establish the PR-HRQOL as a patient-centered outcome measure suitable for clinical and research use in individuals participating in PR. This abstract is funded by: None
Jano et al. (Fri,) conducted a observational in Chronic obstructive pulmonary disease (COPD) (n=49). PR-HRQOL questionnaire vs. FEV1, 6MWD, mMRC, CAT, and CRQ was evaluated on Construct validity (Spearman correlations between PR-HRQOL and COPD severity measures) (p=≤0.01). The novel PR-HRQOL questionnaire demonstrated moderate and statistically significant correlations with 6MWD, mMRC, CAT, and CRQ total scores (p ≤ 0.01), supporting its construct validity in COPD.