Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 23, 2010Journal of HypertensionOpen Access

Maternal high-salt diet during pregnancy was associated with disorganized myofibrillae, mitochondria cristae loss, enhanced S-phase for cardiac cells, and increased cardiac AT1 receptor expression.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does maternal high-salt diet during pregnancy alter fetal cardiac development and the renin-angiotensin system?

Population

Fetal and adult offspring exposed to maternal high-salt diet during pregnancy (preclinical model)

Design

Preclinical

Key result

Maternal high-salt diet during pregnancy was associated with disorganized myofibrillae, mitochondria cristae loss, enhanced S-phase for cardiac cells, and increased cardiac AT1 receptor expression.

Authors

YDYang DingJLJuanxiu LvCMCaiping Mao

Discussion

Loading...

Member takes

Overview

May warrant caution on high-salt diets in pregnancy; leaves open human translation of fetal cardiac effects.

Structured PICO

Does maternal high-salt diet during pregnancy alter fetal cardiac development and the renin-angiotensin system?

P
Population
Fetal and adult offspring exposed to maternal high-salt diet during pregnancy (preclinical model)
I
Intervention
Maternal high-salt diet during pregnancy
O
Outcome
Fetal cardiac structures, cell cycle, renin-angiotensin system (RAS), and epigenetic alternations in the heartsurrogate

Maternal high-salt diet during pregnancy induces developmental changes in fetal cardiac cells and the renin-angiotensin system, which persist into adulthood.

Cite This Study

Ding et al. (2010) studied High-salt diet during pregnancy. High-salt diet was evaluated on Fetal cardiac structures, cell cycle, renin-angiotensin system, and epigenetic alternations. Maternal high-salt diet during pregnancy was associated with disorganized myofibrillae, mitochondria cristae loss, enhanced S-phase for cardiac cells, and increased cardiac AT1 receptor expression.

synapsesocial.com/papers/6a0e9c309c1aa67fcac85521https://doi.org/10.1097/hjh.0b013e328337da8f
View Full Paper
Ask AI
Bookmark
Share