What question did this study set out to answer?

The aim is to enhance the comparability of microCT imaging assessments of subchondral bone in osteoarthritis models.

May 21, 2026Osteoarthritis and Cartilage0 citationsOpen Access

Improving comparability of microCT assessment and reporting of subchondral bone in mouse models of osteoarthritis

PDPholpat DurongbhanThe University of Melbourne LELucinda A.E. EvansRoyal Veterinary College DFDavid M. FindlayThe University of Adelaide

Key Points

The aim is to enhance the comparability of microCT imaging assessments of subchondral bone in osteoarthritis models.
Utilized murine models of osteoarthritis for assessment.
Examined diverse definitions of the subchondral region and VOI.
Investigated separation methods for subchondral bone features.
Identified inconsistencies in definitions impacting imaging accuracy.
Demonstrated the need for standardized protocols in microCT analysis.
Highlighted challenges in translating histological data to imaging.

Abstract

Objective: Subchondral bone is a critical component of the osteochondral unit, but its translation from histology to quantitative imaging studies using micro-computed tomography (microCT) remains inconsistent.Definitions diverge on how far the subchondral region extends from the articular surface, how volumes of interest (VOIs) are defined, how subchondral bone plate is separated from subchondral trabecular bone, and whether articular calcified cartilage is included in the analysis.In murine models of osteoarthritis, where tissue dimensions approach the imaging voxel size, these issues are further magnified.

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