Among hospitalized patients undergoing percutaneous left atrial appendage occlusion, women had a higher rate of major in-hospital adverse events compared to men (2.8% vs 1.9%; p<0.01).
Observational (n=9,281)
Yes
Does female sex increase the risk of adverse outcomes in patients undergoing percutaneous left atrial appendage occlusion?
Women undergoing percutaneous left atrial appendage occlusion have a significantly higher risk of major in-hospital adverse events and 30-day readmissions compared to men.
Absolute Event Rate: 2.8% vs 1.9%
p-value: p=<0.01
Abstract Objectives and Background There is insufficient current evidence about whether sex impacts outcomes of percutaneous left atrial appendage occlusion (LAAO). The aim of this study was to investigate the association between sex and short‐term outcomes of LAAO. Methods Patients who were hospitalized and underwent LAAO from October 2015 to December 2017 in the National Readmission Database were queried. The primary endpoint of interest was major in‐hospital adverse events. Secondary endpoints included, 30‐day readmission rate, nonhome discharge, and cost of hospitalization. Propensity score matching (1:1) was performed to compare the outcomes among women and men. Results A total of 9,281 patients were included in the current analysis women = 3,659 (39%); men = 5,622 (61%). Comparing women to men, women had lower prevalence of diabetes mellitus (30.6% vs 35.7%, p < .01), heart failure (28.6% vs 30.8%, p = .03), vascular disease (55.5% vs 69.6%, p < .01) and renal failure (18.3% vs 21.2%, p < .01), and higher CHA 2 DS 2 VASc score (5 IQR4‐6 vs 4 IQR3‐6, p < .01). After propensity‐score matching, women had higher rate of major in‐hospital adverse events (2.8% vs 1.9%; p < .01), and nonhome discharges (11.4% vs 6.7%; p < .01). Additionally, 30‐day readmission rate was higher among women (10% vs 8.6%, p = .03). Conclusion Among hospitalized patients undergoing LAAO, women carry higher risk for major in‐hospital adverse events, nonhome discharge, and 30‐day readmission rates.
Osman et al. (Tue,) conducted a observational in Left atrial appendage occlusion (n=9,281). Female sex vs. Male sex was evaluated on Major in-hospital adverse events (p=<0.01). Among hospitalized patients undergoing percutaneous left atrial appendage occlusion, women had a higher rate of major in-hospital adverse events compared to men (2.8% vs 1.9%; p<0.01).
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