Why the study?
Does long-term cardiac resynchronization therapy improve invasive hemodynamics, ventricular-arterial coupling, and functional status in patients with severe heart failure and left bundle-branch block?
Population
22 patients scheduled for implantation of a cardiac resynchronization therapy device based on conventional…
Comparison
Cardiac resynchronization therapy with… vs Baseline measurements before CRT.
Design
Cohort
Follow-up
6 months
Key result
Long-term cardiac resynchronization therapy at 6 months significantly improved left ventricular ejection fraction from 29% to 40% (P<0.01) and maintained acute hemodynamic improvements.
Authors
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May support sustained CRT benefits in severe HF with LBBB; leaves open confirmation in randomized outcome trials.
Observational (n=22)
Does long-term cardiac resynchronization therapy improve invasive hemodynamics, ventricular-arterial coupling, and functional status in patients with severe heart failure and left bundle-branch block?
Absolute Event Rate: 40% vs 29%
p-value: p=<0.01
Long-term cardiac resynchronization therapy provides sustained improvements in invasive hemodynamics, ventricular-arterial coupling, and mechanical efficiency, which correlate with significant clinical and functional benefits.
Steendijk et al. (2006) conducted an observational in Heart failure (n=22). Cardiac resynchronization therapy (CRT) vs. Baseline was evaluated on Left ventricular ejection fraction (p=<0.01). Long-term cardiac resynchronization therapy at 6 months significantly improved left ventricular ejection fraction from 29% to 40% (P<0.01) and maintained acute hemodynamic improvements.