Genotype-guided warfarin dosing reduced the number of dose titrations during the first 2 weeks compared to traditional dosing (1.77 vs. 2.93), meeting criteria for both non-inferiority and superiority.
RCT (n=322)
Open-label
1:1
Yes
Does genotype-guided warfarin dosing reduce the number of dose titrations in patients of Asian ancestry newly indicated for warfarin?
A pharmacogenetic algorithm for initial warfarin dosing in Asian patients significantly reduces the need for dose titrations in the first two weeks compared to traditional clinical dosing.
Effect estimate: Mean difference -1.16 (95% CI -1.48 to -0.84)
Absolute Event Rate: 1.77% vs 2.93%
p-value: p=<0.001 for both non-inferiority and superiority
Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in South East Asia, involving 322 ethnically diverse patients newly indicated for warfarin (NCT00700895). Clinical follow-up was 90 days. The primary efficacy measure was the number of dose titrations within the first 2 weeks of therapy, with a mean non-inferiority margin of 0.5 over the first 14 days of therapy. Among 322 randomized patients, 269 were evaluable for the primary endpoint. Compared with traditional dosing, the genotype-guided group required fewer dose titrations during the first 2 weeks (1.77 vs. 2.93, difference −1.16, 90% CI −1.48 to −0.84, P < 0.001 for both non-inferiority and superiority). The percentage of time within the therapeutic range over 3 months and median time to stable international normalized ratio (INR) did not differ between the genotype-guided and traditional dosing groups. The frequency of dose titrations (incidence rate ratio 0.76, 95% CI 0.67 to 0.86, P = 0.001), but not frequency of INR measurements, was lower at 1, 2, and 3 months in the genotype-guided group. The proportions of patients who experienced minor or major bleeding, recurrent venous thromboembolism, or out-of-range INR did not differ between both arms. For predicting maintenance doses, the pharmacogenetic algorithm achieved an R2 = 42.4% (P < 0.001) and mean percentage error of −7.4%. Among Asian adults commencing warfarin therapy, a pharmacogenetic algorithm meets criteria for both non-inferiority and superiority in reducing dose titrations compared with a traditional dosing approach, and performs well in prediction of actual maintenance doses. These findings imply that clinicians may consider applying a pharmacogenetic algorithm to personalize initial warfarin dosages in Asian patients. ClinicalTrials.gov NCT00700895 . Registered on June 19, 2008.
Syn et al. (Tue,) conducted a rct in New indication for long-term anticoagulation with warfarin (n=322). Genotype-guided warfarin dosing vs. Traditional clinical dosing was evaluated on Number of dose titrations within the first 2 weeks of therapy (Mean difference -1.16, 95% CI -1.48 to -0.84, p=<0.001 for both non-inferiority and superiority). Genotype-guided warfarin dosing reduced the number of dose titrations during the first 2 weeks compared to traditional dosing (1.77 vs. 2.93), meeting criteria for both non-inferiority and superiority.
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