Coronary artery disease etiology in HFrEF patients was associated with similar one-year mortality compared to idiopathic dilated cardiomyopathy (HR 1.50; 95% CI 0.83-2.70; p=0.182).
Cohort (n=403)
Yes
Does coronary artery disease etiology compared to idiopathic dilated cardiomyopathy affect mortality and readmissions in patients with HFrEF?
In patients hospitalized with HFrEF, those with coronary artery disease etiology have similar one-year mortality and readmission rates compared to those with idiopathic dilated cardiomyopathy, although the latter are more likely to receive a heart transplant.
Effect estimate: HR 1.50 (95% CI 0.83-2.70)
p-value: p=0.182
Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular ejection fraction of <40%. In total, 266 patients (45.6%) had coronary artery disease as main etiology and 137 (23.5%) had idiopathic dilated cardiomyopathy (DCM), and they are the focus of this study. Significant differences were found in Charlson index (CAD 4.4 ± 2.8, idiopathic DCM 2.9 ± 2.4, p < 0.001), and in the number of previous hospitalizations (1.1 ± 1, 0.8 ± 1.2, respectively, p = 0.015). One-year mortality was similar in the two groups: idiopathic DCM (hazard ratio HR = 1), CAD (HR 1.50; 95% CI 0.83–2.70, p = 0.182). Mortality/readmissions were also comparable: CAD (HR 0.96; 95% CI 0.64–1.41, p = 0.81). Patients with idiopathic DCM had a higher probability of receiving a heart transplant than those with CAD (HR 4.6; 95% CI 1.4–13.4, p = 0.012). The prognosis of HFrEF is similar in patients with CAD etiology and in those with idiopathic DCM. Patients with idiopathic DCM were more prone to receive heart transplant.
Vicent et al. (Fri,) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=403). Coronary artery disease (CAD) etiology vs. Idiopathic dilated cardiomyopathy (DCM) etiology was evaluated on One-year mortality (HR 1.50, 95% CI 0.83-2.70, p=0.182). Coronary artery disease etiology in HFrEF patients was associated with similar one-year mortality compared to idiopathic dilated cardiomyopathy (HR 1.50; 95% CI 0.83-2.70; p=0.182).
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