Each 1-unit increase in the triglyceride glucose-body mass index was significantly associated with a 54% increased risk of obstructive sleep apnea (OR 1.54).
Cross-Sectional (n=4,588)
Is an elevated triglyceride glucose-body mass index (TyG-BMI) associated with an increased risk of obstructive sleep apnea in US adults?
Elevated TyG-BMI index is significantly associated with an increased risk of obstructive sleep apnea, suggesting its potential utility as a biomarker for early OSA screening and metabolic risk assessment.
Effect estimate: OR 1.54 (95% CI 1.39-1.70)
p-value: p=<0.0001
Background: The association between TyG-BMI index and the risk of obstructive sleep apnea (OSA), a recently identified biomarker indicating insulin resistance, has yet to be elucidated. Therefore, this study aimed to investigate the association between TyG-BMI index and the risk of OSA using the NHANES database. Methods: Analyses were performed on NHANES data conducted between 2015 and 2018. Logistic regression, stratified analyses, curve-fitting analyses, and threshold effects analyses were utilized to assess the association between TyG-BMI index and the risk of OSA. Results: The study included 4,588 participants. Multifactorial logistic regression analyses found a significant association between TyG-BMI and increased risk of OSA OR: 1.54 (CI:1.39-1.70). In stratified analyses, age interacted with the association, with TyG-BMI being associated with increased risk of OSA only in a subgroup of subjects younger than 60 years 1.31 (1.14-1.50), but gender, smoking status, and alcohol use, did not influence the association. The presence of diabetes, hypertension, and cardiovascular diseases also modified the association, but the number of the included subjects with such conditions was significantly lower, therefore the significance of associations was not observed in those subgroups. Additionally, the risk was non-linearly associated, with the inflection point of TyG-BMI at 12.09, after which the lower slope in the risk was observed. Conclusion: This study demonstrates that elevated levels of the TyG-BMI index are correlated with risk for OSA, underscoring the significance of these findings in facilitating early prevention or timely intervention for OSA.
Meng et al. (Fri,) conducted a cross-sectional in Obstructive sleep apnea (n=4,588). Triglyceride glucose-body mass index (TyG-BMI) vs. Lower TyG-BMI levels was evaluated on Risk of obstructive sleep apnea (OSA) (OR 1.54, 95% CI 1.39-1.70, p=<0.0001). Each 1-unit increase in the triglyceride glucose-body mass index was significantly associated with a 54% increased risk of obstructive sleep apnea (OR 1.54).