Why the study?
Does sensitive cardiac troponin I measurement improve diagnosis and risk stratification for mortality in patients presenting with acute dyspnoea and acute heart failure?
Population
667 consecutive patients presenting to the emergency department with acute dyspnoea, including 377 with…
Comparison
Measurement of sensitive cardiac troponin I… vs Lower strata of s-cTnI and noncardiac causes of…
Design
Cohort, Final diagnosis adjudicated by two independent cardiologists blinded…
Follow-up
median 371 days
Key result
Sensitive cardiac troponin I independently predicted 1-year mortality in acute heart failure (adjusted OR 1.03 per 0.1 μg/L increase, 95% CI 1.02-1.05, P<0.001).
Authors
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May aid mortality risk stratification in acute HF; leaves open whether troponin integration improves outcomes or warrants trials.
Observational (n=667)
Does sensitive cardiac troponin I measurement improve diagnosis and risk stratification for mortality in patients presenting with acute dyspnoea and acute heart failure?
Effect estimate: adjusted OR 1.03 (95% CI 1.02-1.05)
p-value: p=<0.001
Sensitive cardiac troponin I is a strong predictor of short- and long-term prognosis in acute heart failure, with detectable levels even within the normal range independently associated with mortality.
Arenja et al. (2011) conducted an observational in Acute heart failure (n=667). Sensitive cardiac troponin I (s-cTnI) vs. Different strata of s-cTnI levels was evaluated on 1-year mortality (adjusted OR 1.03, 95% CI 1.02-1.05, p=<0.001). Sensitive cardiac troponin I independently predicted 1-year mortality in acute heart failure (adjusted OR 1.03 per 0.1 μg/L increase, 95% CI 1.02-1.05, P<0.001).