• Individual-level tau-PET network characteristics decline progressively from HC to MCI to AD. • Tau network metrics improve diagnostic accuracy over regional SUVR alone. • Global efficiency of the brain tau network is a sensitive biomarker for AD progression. • ApoE4 positivity is associated with reduced tau network efficiency in MCI and AD. • Longitudinal tau network changes track disease progression at the individual level.
Pan et al. (Fri,) studied this question.