Abstract Knee osteoarthritis (OA) remains a leading cause of pain and disability worldwide, and current injectable options such as corticosteroids and hyaluronic acid often provide limited or short‐term benefits. Orthobiologic therapies, particularly platelet‐rich plasma (PRP), have gained attention for their regenerative and anti‐inflammatory potential. PRP plasma gel is a autologous formulation obtained through controlled thermal denaturation of plasma proteins, producing an albumin‐based semisolid matrix subsequently mixed with fresh PRP. This process results in a homogeneous gel capable of sustained release of bioactive growth factors, potentially prolonging intra‐articular residence time and clinical effect compared with conventional PRP. We describe a step‐by‐step technique for preparing PRP plasma gel using standard laboratory equipment, without the need for commercial kits. The method is reproducible, low cost, and suitable for outpatient settings, including resource‐limited environments. Clinical application is shown in knee osteoarthritis, where the formulation can be injected intra‐articularly as an accessible and versatile orthobiologic option. The technique offers technical and economic advantages, with the potential to broaden the use of orthobiologic therapies in daily practice.
Lima et al. (Sun,) studied this question.