Mean nocturnal oxygen saturation < 92% was independently associated with left ventricular diastolic dysfunction in newly diagnosed OSA patients (OR 2.76; 95% CI 1.45-4.91).
Cross-Sectional (n=150)
Is the severity of obstructive sleep apnoea associated with left ventricular diastolic dysfunction in patients without known cardiovascular disease?
In newly diagnosed OSA patients without known cardiovascular disease, the severity of nocturnal oxygen desaturation is independently associated with left ventricular diastolic dysfunction.
Effect estimate: OR 2.76 (95% CI 1.45-4.91)
Obstructive sleep apnoea (OSA) has been linked to increased cardiovascular risk. The present study examined the relationships between respiratory parameters and left ventricular abnormalities in OSA. 150 newly diagnosed OSA patients without any known cardiovascular disease were included in the study (mean ± sd age 49 ± 11 yrs, body mass index 27.1 ± 3.3 kg·m⁻², respiratory disturbance index 41 ± 18 h⁻¹). Haemodynamic, biological, respiratory, cardiac and arterial parameters were assessed at inclusion. 34 (22.7%) patients had a grade 1 left ventricular diastolic dysfunction. Patients with an abnormal diastole were older (p < 0.001) and 81% of them were hypertensive. The only respiratory parameter independently associated with the peak flow velocity in early diastole/peak flow velocity at atrial contraction ratio was mean nocturnal oxygen saturation. 17 (13%) patients had left ventricular hypertrophy. A multivariate analysis showed that clinic systolic blood pressure and mean nocturnal oxygen saturation were independently associated with left ventricular hypertrophy. In a logistic regression model, age ≥ 58 yrs (OR 3.29, 95% CI 1.78-5.64) and mean nocturnal oxygen saturation < 92% (OR 2.76, 95% CI 1.45-4.91) were associated with left ventricular diastolic dysfunction. Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation.
Baguet et al. (Fri,) conducted a cross-sectional in Obstructive sleep apnoea (n=150). Mean nocturnal oxygen saturation < 92% was evaluated on Left ventricular diastolic dysfunction (OR 2.76, 95% CI 1.45-4.91). Mean nocturnal oxygen saturation < 92% was independently associated with left ventricular diastolic dysfunction in newly diagnosed OSA patients (OR 2.76; 95% CI 1.45-4.91).