Cardiac sarcoidosis diagnostics face challenges due to nonspecific criteria and nonhomogeneous inflammation, highlighting the need for further research into its pathophysiology and natural evolution.
This review outlines the current pathophysiological gaps and diagnostic challenges in cardiac sarcoidosis to guide future research and improve diagnostic criteria.
Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research.
Ueberham et al. (2023) conducted a review in Cardiac sarcoidosis. Cardiac sarcoidosis diagnostics face challenges due to nonspecific criteria and nonhomogeneous inflammation, highlighting the need for further research into its pathophysiology and natural evolution.