Increases in population risk factors like diabetes (43%) drove a 33.8% and 22.8% rise in CHD mortality among Mexican men and women from 2000-2012, while treatments prevented 40.3% of deaths.
Observational
What proportion of the change in coronary heart disease mortality in Mexico between 2000 and 2012 is attributable to advances in medical treatments versus changes in population-wide cardiovascular risk factors?
The rising CHD mortality in Mexico is primarily driven by worsening population risk factors like diabetes and physical inactivity, highlighting an urgent need for population-level interventions.
BACKGROUND: Mexico is still in the growing phase of the epidemic of coronary heart disease (CHD), with mortality increasing by 48% since 1980. However, no studies have analyzed the drivers of these trends. We aimed to model CHD deaths between 2000 and 2012 in Mexico and to quantify the proportion of the mortality change attributable to advances in medical treatments and to changes in population-wide cardiovascular risk factors. METHODS: We performed a retrospective analysis using the previously validated IMPACT model to explain observed changes in CHD mortality in Mexican adults. The model integrates nationwide data at two-time points (2000 and 2012) to quantify the effects on CHD mortality attributable to changes in risk factors and therapeutic trends. RESULTS: From 2000 to 2012, CHD mortality rates increased by 33.8% in men and by 22.8% in women. The IMPACT model explained 71% of the CHD mortality increase. Most of the mortality increases could be attributed to increases in population risk factors, such as diabetes (43%), physical inactivity (28%) and total cholesterol (24%). Improvements in medical and surgical treatments together prevented or postponed 40.3% of deaths; 10% was attributable to improvements in secondary prevention treatments following MI, while 5.3% to community heart failure treatments. CONCLUSIONS: CHD mortality in Mexico is increasing due to adverse trends in major risk factors and suboptimal use of CHD treatments. Population-level interventions to reduce CHD risk factors are urgently needed, along with increased access and equitable distribution of therapies.
Arroyo‐Quiroz et al. (Thu,) conducted a observational in Coronary heart disease. Population-wide cardiovascular risk factors and medical treatments was evaluated on Proportion of CHD mortality change attributable to medical treatments and risk factors. Increases in population risk factors like diabetes (43%) drove a 33.8% and 22.8% rise in CHD mortality among Mexican men and women from 2000-2012, while treatments prevented 40.3% of deaths.