Genetic variation related to endothelial dysfunction was predictive of depressive symptoms among patients with established cardiovascular disease.
Observational (n=977)
Does genetic variation related to endothelial function predict depressive symptoms in patients with established cardiovascular disease?
Genetic variation related to endothelial dysfunction may represent a novel mechanism contributing to the high prevalence of depressive symptoms in patients with cardiovascular disease.
Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.
McCaffery et al. (Thu,) conducted a observational in established cardiovascular disease (n=977). Candidate genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism was evaluated on depressive symptoms. Genetic variation related to endothelial dysfunction was predictive of depressive symptoms among patients with established cardiovascular disease.