Sympathetic activation plays a crucial role in the progression of chronic kidney disease and associated cardiovascular events, though the exact underlying mechanisms remain unclear.
Sympathetic overactivity is a crucial mechanism contributing to cardiovascular events, hypertension, and heart failure progression in patients with chronic kidney disease.
The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well established; however, the exact mechanisms contributing to heightened sympathetic tone in patients with chronic kidney disease are unclear. This review analyses potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship.
Schlaich et al. (2008) conducted a review in Chronic kidney disease. Sympathetic activation plays a crucial role in the progression of chronic kidney disease and associated cardiovascular events, though the exact underlying mechanisms remain unclear.
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