A recorded diagnosis of depression was associated with a significantly higher risk of ischaemic heart disease in men (adjusted OR 2.75; 95% CI 1.13 to 6.69; P=0.03), but not in women.
Case-Control (n=1,224)
No
Does depression, anxiety, or antidepressant use increase the risk of developing ischaemic heart disease?
Depression appears to be an independent risk factor for the onset of ischaemic heart disease in men, but not in women.
Effect estimate: Adjusted OR 2.75 (95% CI 1.13 to 6.69)
p-value: p=0.03
Objective: To determine the relation between depression, anxiety, and use of antidepressants and the onset of ischaemic heart disease.Design: Population based case-control study.Setting: All 5623 patients registered with one general practice.Subjects: 188 male cases with ischaemic heart disease matched by age to 485 male controls without ischaemic heart disease; 139 female cases with ischaemic heart disease matched by age to 412 female controls.Main outcome measure: Adjusted odds ratios calculated by conditional logistic regression.Results: The risk of ischaemic heart disease was three times higher among men with a recorded diagnosis of depression than among controls of the same age (odds ratio 3.09; 95% confidence interval 1.33 to 7.21; P = 0.009).This association persisted when smoking status, diabetes, hypertension, and underprivileged area (UPA(8)) score were included in a multivariate model (adjusted 2.75; 1.13 to 6.69; P = 0.03).Men with depression within the preceding 10 years were three times more likely to develop ischaemic heart disease than were the controls (3.13; 1.27 to 7.70; P = 0.01).Men with ischaemic heart disease had a higher risk of subsequent ischaemic heart disease than men without ischaemic heart disease (adjusted 2.34; 1.34 to 4.10; P = 0.003).Depression was not a risk factor for ischaemic heart disease in women on multivariate analysis (adjusted 1.34; 0.70 to 2.56; P = 0.38).Anxiety and subsequent ischaemic heart disease were not significantly associated in men or women.Conclusion: Depression may be an independent risk factor for ischaemic heart disease in men, but not in women.
A Sat, study conducted a case-control in ischaemic heart disease (n=1,224). Depression vs. No depression was evaluated on Onset of ischaemic heart disease (Adjusted OR 2.75, 95% CI 1.13 to 6.69, p=0.03). A recorded diagnosis of depression was associated with a significantly higher risk of ischaemic heart disease in men (adjusted OR 2.75; 95% CI 1.13 to 6.69; P=0.03), but not in women.