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S ummary . An analogue model of human granulopoiesis incorporating feedback control is presented which is less restricted than previous models. The model simulates kinetic data from human DF 32 P and 3 H‐thymidine labelling experiments, and the data obtained by Morley & Stohlman in mice (1970) following destruction of four‐fifths of the marrow. Support for King‐Smith & Morley's (1970) suggestion that cyclic neutropenia may be a stem cell defect is forthcoming, but only after the addition of a further negative feedback loop simulating a granulocyte‘chalone’ or a considerable reduction in the time required for precursor cell division. The value of the model in the interpretation and design of kinetic studies, particularly in the non‐steady state, is discussed.
J. Reeve (Sun,) studied this question.