A genome-wide linkage scan in mice identified significant linkage for systolic blood pressure on chromosome 10 (LOD=4.9) and chromosome 13 (LOD=3.3).
This study provides the first genome-wide linkage scan for blood pressure genes in mice, identifying significant loci on chromosomes 10 and 13.
Effect estimate: LOD 4.9
Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant linkage was observed in the F2s on chromosome 10 (logarithm of the odds score LOD=4.9) and on chromosome 13 in the M spretus backcross (LOD=3.3), with additional suggestive LODs on chromosomes 2, 6, 8, and 18. In addition, several suggestive linkages were observed for phenotypes associated with human hypertension. Our study is the first reported genome-wide linkage scan for blood pressure genes in the mouse.
Wright et al. (1999) studied Hypertension. Interval linkage mapping / Genome scan was evaluated on Systolic blood pressure loci (LOD 4.9). A genome-wide linkage scan in mice identified significant linkage for systolic blood pressure on chromosome 10 (LOD=4.9) and chromosome 13 (LOD=3.3).
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