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May 29, 2026International Journal of Molecular SciencesOpen Access

Fibromyalgia: A Multifactorial Pain Disorder

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Authors

TATomohiko Aoe

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Overview

Hypothesis article discusses pain subgroups in fibromyalgia, suggesting improvements in diagnosis and treatment options.

Key Points

  • This article aims to explore the multifactorial nature of fibromyalgia and its associated pathophysiologies.
  • Divided fibromyalgia patients into low and normal pain threshold subgroups.
  • Analyzed these subgroups using resting-state functional magnetic resonance imaging.
  • Provided a comprehensive overview of fibromyalgia's pathogenesis.
  • Identified distinct characteristics in nociplastic pain among subgroups.
  • Observed variations in sensory processing based on pain thresholds.
  • Emphasized the need for individualized treatment approaches based on subgroup characteristics.

Cite This Study

Tomohiko Aoe (2026) studied this question.

synapsesocial.com/papers/6a192ee7fab5b468c4418346https://doi.org/10.3390/ijms27114813
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