Pomelo-derived exosomes suppress vesicular stomatitis virus infection through GSK3β dependent regulation of innate immune signaling | Synapse
May 29, 2026
Pomelo-derived exosomes suppress vesicular stomatitis virus infection through GSK3β dependent regulation of innate immune signaling
Key Points
This research aims to investigate the antiviral effects of pomelo-derived exosomes against vesicular stomatitis virus (VSV) infection and their regulatory role in innate immune signaling.
Utilized sodium alginate to encapsulate pomelo-derived extracellular vesicles.
Evaluated the anti-VSV activity of these exosomes in vitro.
Analyzed the regulation of GSK3β/STAT1-related signaling pathways.
Anti-VSV activity is linked to GSK3β-dependent modulation of innate immune signaling pathways.
Abstract
Pomelo-derived extracellular vesicles, especially after sodium alginate encapsulation, show anti-VSV activity and may regulate GSK3β/STAT1-related innate immune signaling.