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February 14, 2008European Neurology

Double-Blind Study of Nimodipine in Non-Severe Stroke

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Why the study?

Does nimodipine improve neurologic outcomes in patients with mild to moderate acute ischemic stroke?

Population

52 patients with acute ischemic stroke of mild or moderate severity, with treatment started within 48 hours…

Comparison

Nimodipine 30 mg orally q.i.d. for 14 days. vs Placebo.

Design

RCT, randomized, double-blind

Follow-up

4 months

Authors

JBJ BogousslavskyFRF RégliVZVéronique Zumstein

Discussion

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Overview

Nimodipine should not be used in mild-moderate acute ischemic stroke; confirms lack of benefit on neurologic recovery.

Structured PICO

Does nimodipine improve neurologic outcomes in patients with mild to moderate acute ischemic stroke?

P
Population
52 patients with acute ischemic stroke of mild or moderate severity (Mathew scale sum score between 50 and 75), with treatment started within 48 hours of infarct.
I
Intervention
Nimodipine 30 mg orally q.i.d. for 14 days.
C
Comparator
Placebo.
O
Outcome
Mathew scale scores (repeated measurements over 4 months).

Oral nimodipine initiated within 48 hours of symptom onset did not improve neurologic recovery in patients with mild to moderate acute ischemic stroke.

Limitations

  • neurologic deficit not being severe enough
  • delay before treatment was too long

Cite This Study

Bogousslavsky et al. (2008) studied this question.

synapsesocial.com/papers/6a197ad4b71d9c859389159ahttps://doi.org/10.1159/000116620
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intravenous Nimodipine West European Stroke Trial (INWEST) of Nimodipine in the Treatment of Acute Ischaemic Stroke1994 · 280 citations
  2. 2Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.1989 · 1,171 citations
  3. 3Oral Nimodipine in Aneurysmal Subarachnoid Hemorrhage: A Critical Propensity Score-Matched Reevaluation in a Contemporary Cohort2026
  4. 4Nimodipine Neuroprotection in Cardiac Valve Replacement1996 · 104 citations
  5. 5Cerebrospinal Fluid Concentrations of Nimodipine Correlate With Long-term Outcome in Aneurysmal Subarachnoid Hemorrhage: Pilot Study2019 · 13 citations