September 15, 1986Open Access

A cytosine·cytosine base paired parallel DNA double helix with thymine·thymine bulges

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Abstract

500 MHz 1H NMR studies using 2D-NOESY indicate that the oligonucleotide d(CTCTCT) at low pH forms a parallel double helix with cytosine . cytosine base pairs and thymine . thymine bulges. This unusual structure may explain the hypersensitivity of S1 nuclease at low pH towards supercoiled plasmids containing d(CT)n inserts.

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Sarma et al. (Mon,) studied this question.

synapsesocial.com/papers/6a19b5471d4d911c80ea86c1 https://doi.org/https://doi.org/10.1016/0014-5793(86)80902-4

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