Atrioventricular junction ablation in CRT-ICD patients with permanent AF significantly reduced all-cause ICD shocks compared to rate-slowing drugs (IRR 0.18; 95% CI 0.10-0.32; P<0.001).
Meta-Analysis (n=3,358)
Yes
Does atrioventricular junction ablation reduce all-cause ICD shocks and hospitalizations in CRT-ICD patients with permanent atrial fibrillation compared to rate-slowing drugs?
In patients with permanent AF treated with CRT-ICD, atrioventricular junction ablation significantly reduces the burden of ICD shocks and hospitalizations compared to rate-slowing drugs.
Effect estimate: IRR 0.18 (95% CI 0.10-0.32)
Absolute Event Rate: 8% vs 43.6%
p-value: p=< 0.001
AIMS: We sought to determine whether atrioventricular junction ablation (AVJA) in patients with cardiac resynchronization therapy (CRT) implantable cardioverter-defibrillator (ICD) and with permanent atrial fibrillation (AF) has a positive impact on ICD shocks and hospitalizations compared with rate-slowing drugs. METHODS AND RESULTS: This is a pooled analysis of data from 179 international centres participating in two randomized trials and one prospective observational research. The co-primary endpoints were all-cause ICD shocks and all-cause hospitalizations. Out of 3358 CRT-ICD patients (2720 male, 66.6 years), 2694 (80%) were in sinus rhythm (SR) and 664 (20%) had permanent AF-262 (8%) treated with AVJA (AF + AVJA) and 402 (12%) treated with rate-slowing drugs (AF + Drugs). Median follow-up was 18 months. The mean (95% confidence intervals) annual rate of all-cause ICD shocks per 100 patient years was 8.0 (5.3-11.9) in AF + AVJA, 43.6 (37.7-50.4) in AF + Drugs, and 34.4 (32.5-36.5) in SR patients, resulting in incidence rate ratio (IRR) reductions of 0.18 (0.10-0.32) for AF + AVJA vs. AF + Drugs (P < 0.001) and 0.48 (0.35-0.66) for AF + AVJA vs. SR (P < 0.001). These reductions were driven by significant reductions in both appropriate ICD shocks IRR 0.23 (0.13-0.40), P < 0.001, vs. AF + Drugs and inappropriate ICD shocks IRR 0.09 (0.04-0.21), P < 0.001, vs. AF + Drugs. Annual rate of all-cause hospitalizations was significantly lower in AF + AVJA vs. AF + Drugs IRR 0.57 (0.41-0.79), P < 0.001 and SR IRR 0.85 (073-0.98), P = 0.027. CONCLUSION: In AF patients treated with CRT, AVJA results in a lower incidence and burden of all-cause, appropriate and inappropriate ICD shocks, as well as to fewer all-cause and heart failure hospitalizations. CLINICAL TRIAL REGISTRATION: NCT00147290, NCT00617175, NCT01007474.
Gasparini et al. (Mon,) conducted a meta-analysis in Permanent atrial fibrillation in patients with CRT-ICD (n=3,358). Atrioventricular junction ablation (AVJA) vs. Rate-slowing drugs was evaluated on All-cause ICD shocks (annual rate per 100 patient years) (IRR 0.18, 95% CI 0.10-0.32, p=< 0.001). Atrioventricular junction ablation in CRT-ICD patients with permanent AF significantly reduced all-cause ICD shocks compared to rate-slowing drugs (IRR 0.18; 95% CI 0.10-0.32; P<0.001).