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March 24, 2014PLoS ONEOpen Access

There were no correlations between the heart weight:body weight index and mRNA or protein levels of fetal genes; the only correlates of non-indexed heart weight were protein levels of α-MHC (ρ = 1, P<0.05) and ANP (ρ = -0.73, P<0.05).

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Why the study?

Are fetal genes consistent biomarkers of cardiac hypertrophy in rodent models of diabetes?

Population

94 systematically selected studies of rodent models of diabetes

Design

Systematic_review

Authors

ECEmily J. CoxSMSusan A. Marsh

Discussion

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Overview

Fetal genes unreliable as hypertrophy biomarkers in diabetic rodent models; challenges their validity and leaves open identification of reliable alternatives.

Structured PICO

Are fetal genes consistent biomarkers of cardiac hypertrophy in rodent models of diabetes?

P
Population
94 systematically selected studies of rodent models of diabetes
I
Intervention
Measurement of fetal gene program (FGP) markers (α-MHC, β-MHC, SERCA, ANP, BNP)
O
Outcome
Correlation between heart weight:body weight index or non-indexed heart weight and mRNA/protein levels of fetal genessurrogate

The fetal gene program is confounded by diabetogenic methods and is not a reliable biomarker for cardiac hypertrophy in rodent models of diabetes.

Cite This Study

Cox et al. (2014) studied this question.

synapsesocial.com/papers/6a1b9c3039ea7417dc43088ahttps://doi.org/10.1371/journal.pone.0092903
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