Cartilage-affinity tea polyphenol liposomes alleviate osteoarthritis by suppressing the PI3K/Akt signaling pathway

Key Points

• The study aims to investigate the effects of tea polyphenol liposomes on chondrocyte health and osteoarthritis.
• Utilized cartilage-affinity liposomes for targeted delivery of tea polyphenols.
• Assessed mitochondrial stress mitigation and chondrocyte homeostasis in vitro and in vivo.
• Examined PI3K/Akt signaling pathway suppression as a mechanism of action.
• Tea polyphenols significantly reduced mitochondrial stress in chondrocytes, enhancing cell survival.
• Inhibition of the PI3K/Akt signaling pathway was confirmed as a key protective mechanism (p<0.05).
• Enhanced in vivo efficacy of the cartilage-affinity liposomes was observed compared to free tea polyphenols (p<0.01).