In healthy children and adolescents, distensibility of the ascending aorta decreased significantly with age by an average of 5.1 10^-3 kPa^-1 per year, while the wall stiffness index increased.
Cross-Sectional (n=165)
No
This study establishes normal age-related reference values for ascending aortic distensibility and stiffness index in healthy children and adolescents, demonstrating that distensibility decreases and stiffness increases with age.
Effect estimate: average decrease of 5.1 10^-3 kPa^-1 per year (95% CI 3.9-6.8)
p-value: p=<0.001
BACKGROUND: Compliance of the aorta is important in maintaining normal cardiovascular physiology. Pathological conditions can induce changes in elastic properties, having profound effects on their prognosis. The aim of this study was to establish age-related reference values for distensibility and wall stiffness index of the ascending aorta. METHODS AND RESULTS: A total of 165 normal subjects (mean age, 11.92±4.0 years) were investigated on transthoracic echocardiography. Ascending aortic diameter was recorded in M-mode above the sinotubular junction. Blood pressure was measured simultaneously at the right arm. Aortic pulse pressure, distensibility and aortic wall stiffness index were calculated offline. Distensibility decreased significantly with age (r=-0.462, P<0.001); the regression line indicated an average decrease of 5.1 10(-3)kPa(-1) (95% confidence interval CI: 3.9-6.8 10(-3)kPa(-1)) per year. Significant correlations could be found between distensibility and weight, height, body surface area (BSA) and body mass index (BMI) (P<0.001). Stiffness index increased significantly with age (r=0.399, P<0.001); the regression line indicated an average increase of 0.066 (95% CI: 0.047-0.085) per year; significant correlations could be found between wall stiffness index and weight, height, BSA and BMI (P<0.001). The 2.5th and 97.5th percentiles of the distribution of distensibility and stiffness index related to age, weight, height, BSA and BMI were calculated. CONCLUSIONS: Normal values of arterial elastic properties throughout childhood and adolescence have been provided, and might serve as a reference for individuals with cardiovascular and metabolic disease.
Hauser et al. (2013) conducted a cross-sectional in Healthy children and adolescents (n=165). Age was evaluated on Distensibility of the ascending aorta (average decrease of 5.1 10^-3 kPa^-1 per year, 95% CI 3.9-6.8, p=<0.001). In healthy children and adolescents, distensibility of the ascending aorta decreased significantly with age by an average of 5.1 10^-3 kPa^-1 per year, while the wall stiffness index increased.