Structure and Function of Human Growth Hormone: Implications for the Hematopoietins

CONTENTS PERSPECTIVE AND OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329 LIGANDS FOR HEMATOPOIETIC RECEPTORS ARE FOUR-HELIX BUNDLES 331 THE EXTRACELLULAR DOMAINS OF THE HEMATOPOIETIC RECEPTORS 334 ONE hGH BINDS TWO RECEPTORS 337 Mutational Analysis 337 Crystallographic Analysis 341 FUNCTIONAL AND STRUCTURAL EPITOPES ON hGH OVERLAP 342 IMPLICATIONS FOR OTHER HEMATOPOIETINS 344 Hematopoietic Hormones 344 Extracellular Receptor Domains 345 MECHANISM(S) FOR ACTIVATION OF THE GROWTH-HORMONE RECEPTOR 346 FUTURE APPLICATIONS ... .... 348