Nine established risk factors and emerging genetic loci account for the majority of myocardial infarction cases in very young South Asians, though the complete risk profile remains unknown.
Nine modifiable risk factors and emerging genetic loci are key contributors to the high burden of premature coronary artery disease in very young South Asians.
PURPOSE OF REVIEW: It is only over the last few decades that the impact of coronary artery disease (CAD) in very young South Asian population has been recognized. There has been a tremendous interest in elucidating the causes behind this phenomenon and these efforts have uncovered several mechanisms that might explain the early onset of CAD in this population. The complete risk profile of very young South Asians being affected by premature CAD still remains unknown. RECENT FINDINGS: The existing data fail to completely explain the burden of premature occurrence of CAD in South Asians especially in very young individuals. Results from some studies identified nine risk factors, including low consumption of fruits and vegetables, smoking, alcohol, diabetes, psychosocial factors, sedentary lifestyle, abdominal obesity, hypertension and dyslipidemia as the cause of myocardial infarction in 90% of the patients in this population. Recent large genome-wide association studies have discovered the association of several novel genetic loci with CAD in South Asians. Nonetheless, continued scientific efforts are required to further our understanding of the causal risk factors of CAD in South Asians to address the rising burden of CVD in this vulnerable population. SUMMARY: In this review, we discuss established and emerging risk factors of CAD in this population.
Gupta et al. (Wed,) conducted a review in Coronary artery disease / Myocardial infarction. Risk factors (diet, smoking, alcohol, diabetes, psychosocial, sedentary lifestyle, obesity, hypertension, dyslipidemia) was evaluated on Myocardial infarction. Nine established risk factors and emerging genetic loci account for the majority of myocardial infarction cases in very young South Asians, though the complete risk profile remains unknown.