White-coat hypertension was diagnosed in 33.1% of grade 1 hypertensive patients using 24-hour ABPM, with female sex, age, hypercholesterolemia, and physical inactivity increasing the odds of WCH.
Observational (n=28,198)
Open-label
Yes
What is the prevalence and what are the predictive factors of white-coat hypertension in patients with grade 1 hypertension?
In patients with grade 1 hypertension, assessing exclusively 24-hour BP averages may overestimate white-coat hypertension compared to using 24-hour, daytime, and nighttime averages.
Objective: Current ESH guidelines recommend home and/or ambulatory blood pressure monitoring (ABPM) when white-coat hypertension (WCH) is suspected, particularly in people with grade 1 hypertension (gr. 1 HT). Our aim was to assess the prevalence of WCH in patients with gr. 1 HT defined by office BP measurement, and to determine the relevant predictive factors in WCH compared to sustained hypertension. Design and method: Data were collected from the Hungarian ABPM Registry, which is an ongoing, multicenter, open-label, observational study. Adult patients (n=62,194, age: 56.15±15.18 years, female: 54.5%) with known or suspected hypertension were included. Validated Meditech ABPM-06 was used. Data analyzed in this report were collected between 01.03.2021-17.11.2025, we focused only on gr. 1 HT patients (n=28,198, 45.3%) who has similar patient characteristics (age: 55.76±15.30 years, female: 52.7%). Results: The suspicion of WCH was the indication of ABPM in 11.3% (n=3,182) of the gr.1 HT patients. 69.8% (n=19,682) of gr. 1. HT patients were on antihypertensive treatment. Based solely on the 24-hour ABPM results WCH was diagnosed in 33.1% (n=9,331) of the gr. 1 HT patients. 74.3% (n=6,929) of them were treated, defined as white-coat uncontrolled hypertension (WUCH) and 25.7% (n=2,402) were untreated. The proportion of WCH patients was 20.8% (n=5,868) if we considered 24-hour, daytime and nighttime averages as well. In this case the proportion of WUCH patients was 73.9% (n=4,338). Female sex, age, hypercholesterolemia and physical inactivity increased the odds of WCH compared to sustained hypertension in patients with gr. 1 HT based on the ABPM results. (See table)Conclusions: If we consider all the three ABPM averages (24-hour, daytime and nighttime), the proportion of WCH patients was twice, if we use only the 24-hour averages it was three times higher than it was suspected according to the indication of ABPM. Assessing exclusively 24-hour BP average may lead to the overestimation of WCH. Female sex, age, hypercholesterolemia and physical inactivity were significant predictive factors of WCH compared to sustained hypertension in patients with gr. 1 HT.
Pásztor et al. (Fri,) conducted a observational in Grade 1 hypertension (n=28,198). White-coat hypertension vs. Sustained hypertension was evaluated on Prevalence of white-coat hypertension (WCH). White-coat hypertension was diagnosed in 33.1% of grade 1 hypertensive patients using 24-hour ABPM, with female sex, age, hypercholesterolemia, and physical inactivity increasing the odds of WCH.