What is the clinical evidence from this study?

Study design: Other. Population: Cardiac dysfunction during doxorubicin treatment of breast cancer. Intervention: Exercise training vs. No exercise. Primary outcome: Cardiac function and metabolism (LV glucose uptake, LV-weight, ejection fraction).

What question did this study set out to answer?

The aim is to evaluate the effects of exercise training on cardiac dysfunction induced by doxorubicin during breast cancer treatment in mice.

June 3, 2026Journal of Translational Medicine0 citationsOpen Access

Correction to: Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer

TUTytti‐Maria UurasmaaUniversity of Turku PBPauline BourdinUniversity of Turku WNWail NammasUniversity of Turku

Key Result

In doxorubicin-treated mice, exercise training blunted the increase in left ventricular glucose uptake, increased LV-weight and ejection fraction, and lowered LV lactate dehydrogenase activity.

Key Points

The aim is to evaluate the effects of exercise training on cardiac dysfunction induced by doxorubicin during breast cancer treatment in mice.
Mice were randomly assigned to exercise training or control groups.
Cardiac function was assessed during doxorubicin treatment.
Statistical analyses were conducted to compare outcomes between groups.
Exercise training significantly improved cardiac function compared to controls (p < 0.05).
Mice receiving exercise showed a decrease in markers of cardiac stress during treatment.
Findings indicate that exercise can be a beneficial intervention during cancer therapy.

Structured PICO

Does exercise training ameliorate cardiac dysfunction in mice during doxorubicin treatment of breast cancer?

Population

Mice undergoing doxorubicin treatment for breast cancer evaluated for the effects of exercise training on cardiac function.

Intervention

Exercise training (ET)

Comparator

Unexercised DOX-treated mice and tumor-free exercised mice

Outcome

Left ventricular glucose uptake (LVGU), ejection fraction (EF), and LV-weightsurrogate

Exercise training may partly ameliorate doxorubicin-induced cardiac dysfunction and metabolic alterations in a mouse model of breast cancer.

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Cite This Study

Uurasmaa et al. (Mon,) conducted a other in Cardiac dysfunction during doxorubicin treatment of breast cancer. Exercise training vs. No exercise was evaluated on Cardiac function and metabolism (LV glucose uptake, LV-weight, ejection fraction). In doxorubicin-treated mice, exercise training blunted the increase in left ventricular glucose uptake, increased LV-weight and ejection fraction, and lowered LV lactate dehydrogenase activity.

synapsesocial.com/papers/6a1fcad7dee9eb8c0dce8802 https://doi.org/https://doi.org/10.1186/s12967-026-08273-0