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This research investigates how macrophages synthesize plasma membrane after phagocytosis of polystyrene latex particles.

Plasma Membrane Synthesis in the Macrophage following Phagocytosis of Polystyrene Latex Particles

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Randomized trial demonstrates plasma membrane synthesis in macrophages, suggesting membrane restoration mechanisms.

This research investigates how macrophages synthesize plasma membrane after phagocytosis of polystyrene latex particles.
Analyzed changes in plasma membrane and phagolysosomal composition in mouse peritoneal macrophages after phagocytosis.
Measured 5′-nucleotidase activity, cholesterol, and phospholipid levels over 12 hours.
Examined the effect of exogenous cholesterol and inhibition of protein and RNA synthesis.
Cholesterol and phospholipid levels increased after a lag of 6 hours, proportional to the latex ingested.
5′-nucleotidase activity returned to control levels by 10 to 12 hours post-phagocytosis.
Inhibition of cholesterol presence prevented restoration of plasma membrane functions and 5′-nucleotidase activity.

Werb et al. (1972) studied this question.

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View Full Paper

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Authors

Randomized trial demonstrates plasma membrane synthesis in macrophages, suggesting membrane restoration mechanisms.

This research investigates how macrophages synthesize plasma membrane after phagocytosis of polystyrene latex particles.
Analyzed changes in plasma membrane and phagolysosomal composition in mouse peritoneal macrophages after phagocytosis.
Measured 5′-nucleotidase activity, cholesterol, and phospholipid levels over 12 hours.
Examined the effect of exogenous cholesterol and inhibition of protein and RNA synthesis.
Cholesterol and phospholipid levels increased after a lag of 6 hours, proportional to the latex ingested.
5′-nucleotidase activity returned to control levels by 10 to 12 hours post-phagocytosis.
Inhibition of cholesterol presence prevented restoration of plasma membrane functions and 5′-nucleotidase activity.

Werb et al. (1972) studied this question.

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