Adibendan demonstrated both peripheral vasodilator and cardiac positive inotropic actions, increasing LV dP/dt60, stroke volume, and cardiac output similarly to dobutamine.
Does adibendan improve haemodynamic parameters compared to nitroprusside and dobutamine in conscious dogs?
Adibendan exhibits a dual mechanism of action as both a positive inotrope and a peripheral vasodilator in a canine model.
This study was performed to investigate whether cardiac positive inotropic as well as peripheral vasodilator properties of adibendan contribute to its overall haemodynamic profile in conscious dogs. 2. Haemodynamic measurements were carried out in conscious chronically instrumented dogs after administration of adibendan, sodium nitroprusside or dobutamine. 3. The cardiovascular changes induced by adibendan (0.01 and 0.03 mg kg-1) resembled those of dobutamine (1.0-4.0 micrograms kg-1 min-1): left ventricular dP/dt60 (LV dP/dt60), stroke volume (SV) and cardiac output (CO) increased to a similar extent, but mean arterial pressure (MAP) and heart rate (HR) remained unchanged. 4. In contrast to dobutamine, higher doses of adibendan (0.1-1.0 mg kg-1) decreased MAP and LVEDP. These effects were of a similar magnitude to those observed following nitroprusside administration (0.5-12.5 micrograms kg-1 min-1). In contrast to nitroprusside, adibendan still showed additional effects on LV dP/dt60 and CO. 5. From these results, it is concluded that both the peripheral vasodilator and the cardiac positive inotropic action of adibendan contribute to its overall haemodynamic profile.
Dorszewski et al. (Thu,) reported a other. Adibendan vs. Sodium nitroprusside and dobutamine was evaluated on Haemodynamic measurements (LV dP/dt60, SV, CO, MAP, HR, LVEDP). Adibendan demonstrated both peripheral vasodilator and cardiac positive inotropic actions, increasing LV dP/dt60, stroke volume, and cardiac output similarly to dobutamine.