Exercise training promotes physiological and molecular benefits in cardiovascular diseases, including epigenetic modifications, reduced inflammation, and improved cardiovascular resilience.
Does aerobic exercise training improve cardiac dysfunction and reduce fibrosis in chronic Chagas cardiomyopathy?
This editorial highlights the physiological benefits of aerobic exercise training, specifically its ability to reduce fibrosis and attenuate cardiac dysfunction in chronic Chagas cardiomyopathy.
ExT can be mainly divided into 2 different types: aerobic ExT (De Sousa and Improta-Caria, 2022) and resistance ExT (Paluch et al., 2024), and more recently, more evidence has emerged about high intensity interval training (HIIT) (Wewege et al., 2018). Aerobic ExT is the most suitable for individuals with CVDs. In this context, Improta-Caria et al. demonstrated that 5 weeks of aerobic ExT was able to reduce collagen content in the hearts of mice with chronic Chagas cardiomyopathy, as well as decrease collagen content in skeletal muscles. This beneficial effect of ExT in reducing collagen in cardiac tissue promoted improvement in cardiac arrhythmias, attenuating cardiac dysfunction in these animals. It is important to emphasize that chronic Chagas cardiomyopathy is a disease that induces an increased inflammatory and fibrotic profile in both cardiac and skeletal muscle (Meira et al., 2019), in addition to promoting severe arrhythmias and cardiac dysfunction (Bocchi et al., 2017).In this context, ExT is a key tool in cardiac rehabilitation, both for chronic Chagas cardiomyopathy and other types of cardiomyopathies (Price et al., 2016)
Improta‐Caria et al. (Wed,) conducted a editorial in Cardiovascular diseases. Exercise training was evaluated. Exercise training promotes physiological and molecular benefits in cardiovascular diseases, including epigenetic modifications, reduced inflammation, and improved cardiovascular resilience.