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ALS and FTLD exhibit distinct, cell-type-specific transcriptomic alterations in the frontal cortex, including dysregulated alternative polyadenylation (APA) patterns that can be predicted by integrating transcript sequences and RNA-binding protein expression. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Single-nucleus transcriptome atlas of orbitofrontal cortex in ALS with a deep learning-based decoding of alternative polyadenylation mechanisms

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