An irregular surface of atrial myxomas was significantly more frequent in patients who experienced embolic events compared to those without embolism (76.47% vs. 36.28%, p=0.0273).
Observational (n=130)
Yes
What are the neurological manifestations and associated risks in patients with atrial myxoma?
Atrial myxomas frequently manifest as cerebral infarction, and an irregular tumor surface is associated with a high risk of embolic events.
Absolute Event Rate: 76.47% vs 36.28%
p-value: p=0.0273
Atrial myxoma is the most common type of primary cardiac tumor and it is closely associated with stroke in adults. Early diagnosis and treatment of atrial myxomas is essential for the prevention of embolic events. The aim of the present study was to assess neurological complications associated with atrial myxoma. The neurological signs of atrial myxoma were retrospectively assessed in individuals who underwent treatment at West China Hospital (Chengdu, China) and The Affiliated Hospital of Hainan Medical University (Haikou, China), between March 2003 and February 2015. A total of 130 patients with atrial myxoma were included and 22 (17%) exhibited neurologic signs. These patients were aged 39.9±12.6 years (range, 13-78 years) and there were 13 female and 9 male patients. Ischemic cerebral infarct constituted the dominant clinical symptom (68.2%) and 3 patients exhibited concomitant cardiac manifestations. Atrial myxoma was diagnosed by echocardiography in all patients. Irregular surface of atrial myxomas was associated with a high risk of embolic events. The patients with myxoma successfully underwent surgery with no mortality recorded. In conclusion, atrial myxomas frequently manifest as cerebral infarction in individuals without cardiovascular risk factors. These tumors more commonly affect the middle cerebral artery. Irregular surface of myxomas appears to be associated with embolic events. Echocardiography may improve the diagnosis and early treatment of atrial myxomas.
Wen et al. (Wed,) conducted a observational in Atrial myxoma (n=130). Embolic events vs. No embolic events was evaluated on Presence of irregular tumor surface (p=0.0273). An irregular surface of atrial myxomas was significantly more frequent in patients who experienced embolic events compared to those without embolism (76.47% vs. 36.28%, p=0.0273).