Orthokeratinized odontogenic cyst (OOC) is an uncommon developmental cyst of odontogenic origin that was considered a variant of the odontogenic keratocyst (OKC). However, extensive research has demonstrated that OOC exhibits distinctive clinical, radiological, and histopathological features, warranting its classification as a distinct pathological entity. Histologically, OOC presents a thin, uniform epithelial lining with a prominent orthokeratinized surface and a distinct granular cell layer, features that clearly differentiate it from the parakeratinized and corrugated epithelial lining typically observed in OKC. OOC shows a slow‐growing, less aggressive behavior and minimal recurrence potential. The preferred treatment is surgical enucleation, and the prognosis is excellent, with recurrence rates reported to be below 2%, in sharp contrast to the 8%–25% observed in OKC following similar management. This case series highlights six OOC cases, elaborating on their clinical, radiographic, and histopathological features to enhance clinicians′ understanding of this rare odontogenic cyst.
Sankari et al. (Thu,) studied this question.