The ALERA v7.3 engine, requiring convergence of at least two independent pathological signals, achieved >99% sensitivity and specificity for predicting cardiovascular disease onset.
Does the ALERA v7.3 engine improve the prediction of cardiovascular disease onset compared to static biomarker thresholds?
Simulated model of cardiovascular failure
ALERA v7.3 engine (a deterministic prognostic framework requiring convergence of at least two independent pathological signals)
Current cardiovascular diagnostic frameworks relying on static biomarker thresholds
Sensitivity and specificity for predicting cardiovascular disease onset
The ALERA v7.3 engine introduces a deterministic multi-signal convergence model that demonstrates >99% sensitivity and specificity for predicting cardiovascular disease onset in simulations.
Current cardiovascular diagnostic frameworks rely on static biomarker thresholds that often result in a high rate of false positives due to physiological noise. This research presents the ALERA v7.3 engine, a deterministic prognostic framework that models cardiovascular failure as a systemic collapse governed by multi-signal convergence. By introducing the Cardiovascular Decay Constant (Vstandard) and a majority-vote logic gate, we simulate the kinetic erosion of hemodynamic stability. Our findings indicate that by requiring the convergence of at least two independent pathological signals (e.g., NT-proBNP, GLS, and Troponin), we achieve > 99% sensitivity and specificity. This model shifts the clinical paradigm from probabilistic risk scoring to deterministic temporal forecasting, identifying the exact window of transition to critical hemodynamic fragility.
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Tanmay Srivastava
University of Georgia
University of Georgia
Opera Software (Ireland)
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Tanmay Srivastava (Tue,) conducted a other in Cardiovascular Disease. ALERA v7.3 engine vs. Static biomarker thresholds was evaluated on Sensitivity and specificity. The ALERA v7.3 engine, requiring convergence of at least two independent pathological signals, achieved >99% sensitivity and specificity for predicting cardiovascular disease onset.
synapsesocial.com/papers/6a2117dfd499ed480b170bd3 — DOI: https://doi.org/10.5281/zenodo.20514392