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Mind-Regulating Acupuncture combined with conventional therapy effectively treats post-stroke depression and improves neurological function, likely by regulating the microbiota-gut-brain axis and enhancing 5-HT and BDNF levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 2025Neuropsychiatric Disease and Treatment11 citationsOpen Access

Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study

JXJingjun XieArmy Medical University JLJinxia LiShihezi University QSQi‐Jian SunSun Yat-sen University

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Abstract

Objective: This study explored the clinical efficacy and mechanisms of Mind-Regulating Acupuncture (MRA) for post-stroke depression (PSD) based on the "microbiota-gut-brain axis" theory. Methods: 92 PSD patients were randomly divided into an observation group (received conventional therapy + MRA) and a control group (conventional therapy only). After 8 weeks of treatment, multiple indicators including depression scores, neurological function scores, and levels of neurotransmitters and gut microbiota were compared. Results: MRA significantly improved depressive symptoms, neurological function, and daily living abilities in PSD patients. It increased serum 5-HT and BDNF levels, and regulated gut microbiota, promoting beneficial bacteria and reducing harmful ones. Conclusion: MRA effectively treats PSD, and its mechanism may involve regulating the "microbiota-gut-brain axis", increasing beneficial gut bacteria, and enhancing 5-HT and BDNF levels.

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