Why the study?
Concentrations of cTnI and cTnT are associated with clinical cardiac outcomes but do not correlate closely in the general population, leading to the hypothesis that they reflect different CV phenotypes and risk factors.
Are concentrations of cTnI and cTnT associated with different cardiovascular risk factors and subclinical left ventricular hypertrophy or dysfunction in a general population without known cardiovascular disease?
Population
1236 women and 1157 men with no known CV disease
Comparison
Concentrations of cTnI vs cTnT
Design
Prospective observational study
Key result
Cardiac troponin I and T concentrations were associated with subclinical LV hypertrophy and dysfunction, with cTnI showing a stronger association with LV mass index than cTnT (P=0.035).
Authors
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May support preferential use of cTnI for subclinical LV assessment in primary prevention; hypothesis-generating and requires prospective validation.
Observational (n=2,393)
Are concentrations of cTnI and cTnT associated with different cardiovascular risk factors and subclinical left ventricular hypertrophy or dysfunction in a general population without known cardiovascular disease?
p-value: p=0.035
In a general population without known cardiovascular disease, cardiac troponin I appears superior to troponin T in predicting subclinical left ventricular hypertrophy.
Lyngbakken et al. (2020) conducted an observational in No known cardiovascular disease (n=2,393). Cardiac troponin I (cTnI) and T (cTnT) concentrations was evaluated on Left ventricular function and structure (global longitudinal strain and LV mass index) (p=0.035). Cardiac troponin I and T concentrations were associated with subclinical LV hypertrophy and dysfunction, with cTnI showing a stronger association with LV mass index than cTnT (P=0.035).