Lisinopril was as effective as nifedipine for blood pressure reduction, but had a significantly lower incidence of clinical side effects (21.3% vs 48.9%, p<=0.01).
RCT (n=136)
Double-blind
Parallel
Yes
Does lisinopril reduce blood pressure compared to nifedipine in patients with mild to severe uncomplicated essential hypertension?
Lisinopril is as effective as nifedipine in treating uncomplicated essential hypertension but offers a better safety profile with fewer clinical side effects.
A total of 136 patients with mild to severe uncomplicated essential hypertension were evaluated in a multicenter, randomized, double-blind, double-placebo, parallel study to compare the effect of lisinopril, a new angiotensin-converting enzyme inhibitor, with that of nifedipine. Following a 2-week placebo control period the patients were treated with either 20-80 mg/day of lisinopril (n = 89) or with 40-80 mg/day of nifedipine (n = 47). Blood pressure was significantly reduced in both groups after 4, 8, and 12 weeks of treatment. There was no difference in the effect of lisinopril compared to nifedipine. No serious clinical or laboratory adverse experiences were observed during the study. The incidence of clinical side effects was significantly lower in the lisinopril group than in the nifedipine group (21.3 vs. 48.9%, p less than or equal to 0.01). There were no significant changes in laboratory data in either group. The results indicate that lisinopril is as effective as nifedipine in the treatment of uncomplicated essential hypertension and that lisinopril is well tolerated and has an acceptable safety profile.
Mörlin et al. (1987) conducted an RCT in Mild to severe uncomplicated essential hypertension (n=136). Lisinopril vs. Nifedipine (40-80 mg/day) was evaluated on Blood pressure reduction. Lisinopril was as effective as nifedipine for blood pressure reduction, but had a significantly lower incidence of clinical side effects (21.3% vs 48.9%, p<=0.01).