To examine how low molecular weight heparin binds to antithrombin, focusing on its structural components.
Analysis of the pentasaccharide structure of low molecular weight heparin.
Identification of critical sulfation at the third residue for binding efficacy.
Investigated the interaction mechanisms between low molecular weight heparin and antithrombin.
The third residue being 3-O-sulfated glucosamine is essential for effective binding to antithrombin.
Structural analysis confirmed specific molecular requirements for heparin's activity.
Abstract
antithrombin 111 (ATIII)?3.4' The third residue of the pentasaccharide is 3-0-sulfated glucosamine, which is critical for binding to ATIII and is only found in the ATIII-Blood, Vol79, No 1 (January 1).