In older patients with heart failure with preserved ejection fraction, the index of microcirculatory resistance was significantly increased and independently predicted elevated left ventricular end-diastolic pressure (β 0.95, p=0.01).
Cross-Sectional (n=87)
No
Is the index of microcirculatory resistance (IMR) associated with left ventricular end-diastolic pressure (LVEDP) in older patients with HFpEF?
Increased IMR and reduced CFR are characteristic of microvascular dysfunction in older HFpEF patients, with IMR independently predicting LVEDP.
Effect estimate: β 0.95 (95% CI 0.67-1.45)
p-value: p=0.01
OBJECTIVE: To study the coronary microvascular function in older patients with heart failure with preserved ejection fraction (HFpEF) using an invasive pressure-temperature sensor guidewire. METHODS: Patients undergoing echocardiography and cardiac catheterization examinations for exertional dyspnea and a positive stress test were retrospectively enrolled from January 2014 to November 2017, and were allocated into the control group or HFpEF group. The HFpEF group was secondary divided into two groups according to the age of 65. Comparing the clinical features and values obtained in examinations between the three groups, multivariate regression analysis was used to analyze the predictors of left ventricle end diastolic pressure (LVEDP). RESULTS: = 31). The coronary flow reserve (CFR) in the older HFpEF and adult HFpEF groups was similarly reduced. In the regression analysis, the IMR linearly correlated to LVEDP, and was the only independent predictor of LVEDP. CONCLUSIONS: An increased IMR and reduced CFR were characteristics of microvascular dysfunction in older HFpEF patients. The IMR independently had a positive linear correlation with LVEDP. Microvascular rarefaction might be a subsequent pathological progression in the development of HFpEF.
Xu et al. (Thu,) conducted a cross-sectional in Heart failure with preserved ejection fraction (HFpEF) (n=87). Heart failure with preserved ejection fraction (HFpEF) vs. Controls without HFpEF (LVEDP ≤ 16 mmHg) was evaluated on Predictors of left ventricle end diastolic pressure (LVEDP) (β 0.95, 95% CI 0.67-1.45, p=0.01). In older patients with heart failure with preserved ejection fraction, the index of microcirculatory resistance was significantly increased and independently predicted elevated left ventricular end-diastolic pressure (β 0.95, p=0.01).