Vitamin D deficiency was associated with an increased risk of atrial fibrillation (OR 1.31; 95% CI 1.06-1.62; P=0.01).
Meta-Analysis (n=27,307)
Is vitamin D deficiency associated with an increased risk of atrial fibrillation?
Vitamin D deficiency is modestly associated with an increased risk of atrial fibrillation, though the association is stronger in case-control studies of chronic AF than in prospective cohorts of new-onset AF.
Odds Ratio: 1.31 (95% CI 1.06–1.62)
p-value: p=0.01
BACKGROUND: There are accumulating studies investigating the association between vitamin D status and the risk of atrial fibrillation (AF). However, the results in these studies were inconsistent in regard to the role of vitamin D deficiency in predicting the development of AF. HYPOTHESIS: Vitamin D deficiency is associated increased risk of AF. METHODS: Using PubMed and Embase databases, we searched for records published before March 2016. Additionally, a manual search was conducted using all review articles on this topic. Of the 587 initially identified records, 8 studies with a total of 27 307 patients were finally analyzed. RESULTS: In the categorical variable analysis, vitamin D deficiency was associated with the occurrence of AF (odds ratio: 1.31, 95% confidence interval: 1.06-1.62, P = 0.01). In the continuous variable analysis, higher vitamin D levels appear to protect against the development of AF (odds ratio: 0.92, 95% confidence interval: 0.87-0.97, P = 0.002). However, the association is weak on the pooled analysis of prospective cohort studies focused on new-onset AF (P = 0.07 and 0.04), whereas the pooled analysis of case-control studies mainly assessing for chronic AF strongly support such an association (both P < 0.0001). CONCLUSIONS: Vitamin D deficiency modestly increases the risk of AF. Further studies are needed to determine the if there is a direct causal relationship between vitamin D levels and AF and whether vitamin D supplements will prevent new-onset AF.
Zhang et al. (Wed,) conducted a meta-analysis in Atrial Fibrillation (n=27,307). Vitamin D deficiency vs. Normal vitamin D levels was evaluated on Occurrence of atrial fibrillation (OR 1.31, 95% CI 1.06-1.62, p=0.01). Vitamin D deficiency was associated with an increased risk of atrial fibrillation (OR 1.31; 95% CI 1.06-1.62; P=0.01).
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