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May 28, 2009International Journal for Numerical Methods in Biomedical Engineering39 citations

Towards computational modelling of aortic stenosis

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RLRaoul van Loon

Key Result

Fluid-structure interaction models of aortic valves demonstrated clinically relevant scenarios for evaluating aortic stenosis severity using various hemodynamic criteria.

Structured PICO

P
Population
Fluid-structure interaction models of bioprosthetic or native aortic valves
E
Exposure
Computational modeling introducing variable stroke volumes, differently shaped valve and root, leaflet fusion or calcifications
O
Outcome
Systolic behavior and severity of occlusions evaluated by geometrical orifice area, trans-valvular pressure gradient, effective orifice area, and Energy loss coefficientsurrogate

Computational fluid-structure interaction models offer a promising approach to simulate and assess the severity of aortic stenosis under various clinically relevant scenarios.

Abstract

Abstract In this paper fluid–structure interaction models of bioprosthetic or native aortic valves are proposed for the assessment of aortic stenosis severity. The fictitious domain approach is applied for the blood–valve interaction and the valve and root geometry are defined such that geometrical changes can easily be made. Clinically relevant scenarios are demonstrated using the models by introducing variable stroke volumes, differently shaped valve and root, leaflet fusion or calcifications. Systolic behaviour of the valves is observed and the severity of the occlusions is evaluated using the following clinically relevant criteria: geometrical orifice area, trans‐valvular pressure gradient, effective orifice area and Energy loss coefficient. Within this context, the benefits, shortcomings and potential of the presented three‐dimensional models are identified and discussed. Copyright © 2009 John Wiley & Sons, Ltd.

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Cite This Study

Raoul van Loon (2009) studied Aortic stenosis. Fluid-structure interaction models was evaluated on Assessment of aortic stenosis severity (geometrical orifice area, trans-valvular pressure gradient, effective orifice area, Energy loss coefficient). Fluid-structure interaction models of aortic valves demonstrated clinically relevant scenarios for evaluating aortic stenosis severity using various hemodynamic criteria.

synapsesocial.com/papers/6a22e4784a4edab11060634ahttps://doi.org/10.1002/cnm.1270
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discrepancies between Doppler and catheter gradients in aortic prosthetic valves in vitro. A manifestation of localized gradients and pressure recovery.1990 · 202 citations
  2. 2Effect of three-dimensional valve shape on the hemodynamics of aortic stenosis2002 · 128 citations
  3. 3Comparison of Valvular Resistance, Stroke Work Loss, and Gorlin Valve Area for Quantification of Aortic Stenosis1995 · 94 citations
  4. 4Dependence of Gorlin formula and continuity equation valve areas on transvalvular volume flow rate in valvular aortic stenosis.1994 · 201 citations
  5. 5Impact of blood pressure on the Doppler echocardiographic assessment of severity of aortic stenosis2006 · 98 citations