Anger attacks in patients with major depressive disorder were independently associated with cholesterol levels ≥200 mg/dL (OR 2.16; 95% CI 1.18-3.94) and >11 years of smoking.
Cross-Sectional (n=333)
Are anger attacks associated with increased cardiovascular risk factors in outpatients with major depressive disorder?
In outpatients with major depressive disorder, concomitant anger attacks are significantly associated with increased cardiovascular risk factors, specifically elevated cholesterol and prolonged smoking history.
Odds Ratio: 2.16 (95% CI 1.18–3.94)
OBJECTIVE: Depression and anger have been separately associated with cardiovascular risk factors. We investigated if major depressive disorder (MDD) with concomitant anger attacks was associated with cardiovascular risk factors. METHOD: We measured total serum cholesterol, glycemia, resting blood pressure, and smoking parameters in 333 (52.9% women) MDD nonpsychotic outpatients, mean age of 39.4 years. MDD was diagnosed with the Structured Clinical Interview (SCID) in accordance with the Diagnostic and Statistic Manual of Mental Disorders, Third Edition, Revised (DSM-III-R). The presence of anger attacks was established with the Massachusetts General Hospital Anger Attacks Questionnaire. RESULTS: In a logistic regression analysis, anger attacks were independently associated with cholesterol levels > or = 200 mg/dL (odds ratio OR, 2.16; 95% confidence interval CI, 1.18-3.94) and years of smoking > 11 (OR, 2.59; 95% CI, 1.32-5.04). CONCLUSIONS: MDD with anger attacks was significantly associated with increased cholesterol levels and years of smoking.
Fráguas et al. (Thu,) conducted a cross-sectional in Major Depressive Disorder (n=333). Anger attacks vs. No anger attacks was evaluated on Cholesterol levels >= 200 mg/dL (OR 2.16, 95% CI 1.18-3.94). Anger attacks in patients with major depressive disorder were independently associated with cholesterol levels ≥200 mg/dL (OR 2.16; 95% CI 1.18-3.94) and >11 years of smoking.