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June 7, 2026Diabetes

1024-OR: Immunologically Distinct Type 1 Diabetes Subgroups Exhibit Divergent Metabolomic Profiles

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Authors

ABAmina BedratNTNathan A. TruchanSJSHUANG JIA

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Overview

Randomized trial analyzes metabolomic differences in immunologically distinct type 1 diabetes subgroups, suggesting implications for personalized treatment.

Key Points

  • To analyze the plasma metabolomic profiles of two immunologically distinct subgroups of type 1 diabetes (T1D).
  • Cohort of 47 individuals with new onset T1D, aged 11.6 years, male=53%.
  • Participants assigned to subgroups using a plasma-induced transcription assay with 97% accuracy.
  • Untargeted plasma metabolomics conducted using liquid chromatography-tandem mass spectrometry.
  • Subgroup 1 showed elevated pro-inflammatory liver-conjugated bile acids and reduced protective secondary bile acids compared to Subgroup 2.
  • Activation of pathways related to inflammation and tissue damage in Subgroup 1, with inhibited metabolic pathways.
  • BA dysregulation identified as a key feature, indicating a potential liver-gut-pancreas axis in T1D.

Cite This Study

Bedrat et al. (2026) studied this question.

synapsesocial.com/papers/6a250c1c7def13d035e1c1a3https://doi.org/10.2337/db26-1024-or
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