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Synapse
June 8, 2026Open Access

Two distinct patterns of progression of sporadic cerebral small vessel disease

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Authors

YCYutong ChenHHHui HongDTDaniel Tozer

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Overview

Cohort study identifies two progression patterns of cerebral small vessel disease, suggesting differing mechanisms of cognitive decline.

Key Points

  • To investigate changes in imaging and cognitive markers during the progression of sporadic cerebral small vessel disease.
  • Cohort study with 496 participants from the RUNDMC cohort analyzed for imaging markers and cognitive decline.
  • Utilized a subtype and stage inference model to identify progression patterns in cSVD.
  • Validated findings in a second cohort (CamcSVD) consisting of 330 participants.
  • Identified two distinct cSVD subtypes: one with early white matter hyperintensity (WMH) increase followed by tissue volume loss.
  • The second atrophy-predominant subtype showed early gray and white matter loss and ventricle enlargement before WMH increases.
  • Notable increase in markers related to idiopathic normal pressure hydrocephalus in the atrophy-predominant subtype.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a265c42ad53cfb9357c58behttps://doi.org/10.17863/cam.130863
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