What is the clinical evidence from this study?

Study design: Case Report. Population: Angina pectoris with normal coronary arteriograms (n=1). Intervention: Induced tachycardia. Primary outcome: Myocardial hypoxia and anaerobic metabolism.

October 10, 1968

Myocardial Hypoxia as the Basis for Angina Pectoris in a Patient with Normal Coronary Arteriograms

Key Result

Induced tachycardia demonstrated myocardial hypoxia and anaerobic metabolism in a 48-year-old woman with angina pectoris and normal coronary arteriograms.

Study Design

Type

Case Report (n=1)

PICO

P

Population

A 48-year-old woman with exertional chest pain typical of angina pectoris, an abnormal exercise electrocardiogram, and normal coronary arteriograms.

E

Exposure / Comparator

Induced tachycardia

O

Primary Outcome

Myocardial hypoxia and anaerobic metabolism

Abstract

Although coronary arteriograms of a 48-year-old woman with exertional chest pain typical of angina pectoris and an abnormal exercise electrocardiogram were normal, myocardial hypoxia and anaerobic metabolism were demonstrated during induced tachycardia and are proposed as the basis of the angina pectoris. A cause of impaired myocardial oxygen metabolism other than obstructive disease of visible coronary arteries is suggested.